I usually play on 9-42 / 9-46, I needed some time to get used to it.
It's very easy to sound too sharp in pitch, either because of the picking hand force of attack, or the fretting hand pressure, especially if your guitar has tall frets. Makes bends and vibrato ridiculously easy, that's for sure, but it breaks, a lot !
For 6€ the set, that is frustrating.
But it could force one to play more delicatly, thus avoiding fatigue.
And I could imagine some creative ideas like alternative tunings with this.